Thurs., Jan. 9 - At 11 am EST (US) Dr. Mosley will be one of three panelists on the Diane Rehm Show (www.thedianerehmshow.org). The other two panelists are Dr. Mark Mattson - researcher at the National Institute on Aging and Dr. Valter Longo, Director, University of Southern California Longevity Institute. They will be discussing the latest research on intermittent fasting.
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Oooo, that sounds interesting, shame we won't get it here
Ballerina x
Ballerina x
Listening to it now on my Tune In Radio app! Just started..
I made some notes...
Diane welcomes the experts and asks about what they've been working on.
Dr Mark Mattson reviewed his work on ADF in mice and how it resulted in longer life and improved brain function
Dr Valter Longo reviewed his work on longer but less frequent fasting...3 or more days fasting once a month in mice and in humans. He reports that he's running 6 clinical trials in cancer patients re efficacy of chemotherapy and protection from side effects of chemo. Preliminary results good, first trial due to complete early next year.
Dr Michael Mosley reports on OUR results (at least I think it's us...we are described as 'my colleagues' who are running a website tracking weightloss of over 5000 people doing 5:2)! He describes how one person he was in contact with reports a big drop in cholesterol, blood pressure and blood glucose.
Diane Rehm admits she's being doing 5:2 and lost 20lbs and is feeling great.
Dr Mattson describes the benefits of fasting on neurone growth, learning and memory in mice. The animals become more resistant to stress and he thinks it's the stress of fasting that actually stimulates this resistance.
Dr Longo responds to Diane's question about how hard it is to fast for 3 days saying that a trial of people doing 5 days fasting with minimal calories found that it was surprisingly acceptable. They expected 50% of folk to drop out but no-one did! Diane says the food on fast days looked dull, Longo responds that it's actually quite nice although not normal fare and only 10% hated the food.
Dr Mosley says it was Dr Mattson's research that really inspired him and that Dr Krista Varady's studies interested him but that he tried Longo's 5 days when he visited him and talked to Krista Varady about ADF but felt neither of these suited him so he went for 2 days a week instead. Dr Mosley says his fasting glucose has reduced dramatically from diabetic levels to normal.
Dr Mattson explains how Alzheimer's disease models in animals have been shown to benefit from intermittent fasting by delaying the onset of dementia in mice genetically predisposed to it by a significant amount.
Dr Mosley says that as Alzheimer's seems to be related to diabetes, the effect on fasting of diabetes might translate to an improvement in dementia.
Diane reads out an email from someone who tried 5:2 but developed palpitations and her doc told her to stop. Dr Mattson says it could be just a coincidence that the palpitations occurred particularly as the studies in mice showed an improvement in cardiac function. Dr Longo talks about the role of the circadian clock in controlling when you should eat and that by throwing 2 fast days in per week can maybe interfere with this and might cause problems. Longo says he prefers skipping one meal every day (lunch in his case) to 5:2. Dr Mosley says he's been in contact with about 10,000 people following his diet and hasn't come across palpitations as a side-effect.
Diane says she has 2oz cheese for breakfast, a yoghurt for lunch and for dinner she has chicken and veg with 2 glasses of champagne!!! She says she knows it's cheating but she's lost 20lbs anyway. Dr Mosley says that what works for you is most important! He has scrambled eggs, no lunch and salmon and veg for dinner but no champagne.
The phone lines are now opened up.
First caller talks about how fasting and feasting reflects our ancient ancestors diet but what about drinking water? Dr Mosley says yes, you must drink plenty.
Second caller...is this a lifestyle change or just short term? Does the weight stay off if you stop? Dr Mattson says that in animals, the reduction in blood pressure etc continues only as long as the IF continues but if they stop fasting, within a couple of weeks their BP goes back up. Dr Mosley says he still fasts once a week and this keeps the benefits going (as shown by Michelle Harvie's research). Dr Longo confirms, it must be a lifestyle change. Forget the idea of 4 or 5 meals a day...its the cause of the obesity epidemic! He talks though about the elderly...aged over 65...who should not lose too much weight as research says they should have a little more weight than younger people.
Third caller asks about what to drink. They all agree water, tea, coffee but avoid diet drinks if possible (they wonder about the metabolic effects of these drinks but the research is not really clear on this particularly in relation to fasting).
Dr Mattson now talks about exercise...it is absolutely OK to exercise on fast days. It makes no sense that our distant ancestors would have survived if they hadn't been able to chase down an antelope when they hadn't eaten! He also mentions that IF and exercise seem to cause similar changes to the body. Dr Mosley recommends exercise for maximum health benefits. Going out for a stroll or a run etc suppresses appetite.
Fourth caller...what about starvation mode? Dr Mosley says this is one of the great myths of diet based on research done on people whose body fat dropped to 8%. In fact, cutting calories for one day increases metabolic rate which would be an evolutionary advantage...more able to get up and find food. Dr Mattson concurs that fasting improves brain function but doesn't know yet...research in progress.
Missed a caller there cos of a phone call..sorry!
Next caller asks about the Fast-5 diet (or 19:5 as we might term it). Dr Mattson says the shift to fat burning occurs at around 12 to 18 hours of fasting so yes, it should work. Dr Mosley says he tried 19:5 and he didn't like it because he loves breakfast!
Next caller asks about using longer fasting in a clinic to counteract cancer. Dr Longo says there are clinics that do long fasts as a treatment for certain diseases. He says it must be done in a clinic though and it may become more widely used in future.
Next caller asks about the carbohydrate content of food especially sugars and its effect on dementia. Dr Mosley promotes the mediterranean diet (which he describes as lots of veggies, not too much meat, a bit of wine, not so much white pasta, rice, bread, sugar etc). He thinks very low carb diet is a bad idea (due to the nutritional content of complex carbs).
Next caller is a competitive athlete...how can he incorporate fasting into his lifestyle? Dr Mosley says exercise in the fasting state results in more fat burning. Dr Mattson agrees that exercise while fasting is good. The main thing is to work out an optimal weight for your sport and adjust fasting to keep at that weight.
Diane asks each expert where fasting research is going.
Dr Longo says the role of fasting on body repair
Dr Mosley says the role of 5:2 on diabetes and reversing diabetes (studies in Norway ongoing)
Dr Mattson says they're trying to extend animal studies to humans.
The End.
Diane welcomes the experts and asks about what they've been working on.
Dr Mark Mattson reviewed his work on ADF in mice and how it resulted in longer life and improved brain function
Dr Valter Longo reviewed his work on longer but less frequent fasting...3 or more days fasting once a month in mice and in humans. He reports that he's running 6 clinical trials in cancer patients re efficacy of chemotherapy and protection from side effects of chemo. Preliminary results good, first trial due to complete early next year.
Dr Michael Mosley reports on OUR results (at least I think it's us...we are described as 'my colleagues' who are running a website tracking weightloss of over 5000 people doing 5:2)! He describes how one person he was in contact with reports a big drop in cholesterol, blood pressure and blood glucose.
Diane Rehm admits she's being doing 5:2 and lost 20lbs and is feeling great.
Dr Mattson describes the benefits of fasting on neurone growth, learning and memory in mice. The animals become more resistant to stress and he thinks it's the stress of fasting that actually stimulates this resistance.
Dr Longo responds to Diane's question about how hard it is to fast for 3 days saying that a trial of people doing 5 days fasting with minimal calories found that it was surprisingly acceptable. They expected 50% of folk to drop out but no-one did! Diane says the food on fast days looked dull, Longo responds that it's actually quite nice although not normal fare and only 10% hated the food.
Dr Mosley says it was Dr Mattson's research that really inspired him and that Dr Krista Varady's studies interested him but that he tried Longo's 5 days when he visited him and talked to Krista Varady about ADF but felt neither of these suited him so he went for 2 days a week instead. Dr Mosley says his fasting glucose has reduced dramatically from diabetic levels to normal.
Dr Mattson explains how Alzheimer's disease models in animals have been shown to benefit from intermittent fasting by delaying the onset of dementia in mice genetically predisposed to it by a significant amount.
Dr Mosley says that as Alzheimer's seems to be related to diabetes, the effect on fasting of diabetes might translate to an improvement in dementia.
Diane reads out an email from someone who tried 5:2 but developed palpitations and her doc told her to stop. Dr Mattson says it could be just a coincidence that the palpitations occurred particularly as the studies in mice showed an improvement in cardiac function. Dr Longo talks about the role of the circadian clock in controlling when you should eat and that by throwing 2 fast days in per week can maybe interfere with this and might cause problems. Longo says he prefers skipping one meal every day (lunch in his case) to 5:2. Dr Mosley says he's been in contact with about 10,000 people following his diet and hasn't come across palpitations as a side-effect.
Diane says she has 2oz cheese for breakfast, a yoghurt for lunch and for dinner she has chicken and veg with 2 glasses of champagne!!! She says she knows it's cheating but she's lost 20lbs anyway. Dr Mosley says that what works for you is most important! He has scrambled eggs, no lunch and salmon and veg for dinner but no champagne.
The phone lines are now opened up.
First caller talks about how fasting and feasting reflects our ancient ancestors diet but what about drinking water? Dr Mosley says yes, you must drink plenty.
Second caller...is this a lifestyle change or just short term? Does the weight stay off if you stop? Dr Mattson says that in animals, the reduction in blood pressure etc continues only as long as the IF continues but if they stop fasting, within a couple of weeks their BP goes back up. Dr Mosley says he still fasts once a week and this keeps the benefits going (as shown by Michelle Harvie's research). Dr Longo confirms, it must be a lifestyle change. Forget the idea of 4 or 5 meals a day...its the cause of the obesity epidemic! He talks though about the elderly...aged over 65...who should not lose too much weight as research says they should have a little more weight than younger people.
Third caller asks about what to drink. They all agree water, tea, coffee but avoid diet drinks if possible (they wonder about the metabolic effects of these drinks but the research is not really clear on this particularly in relation to fasting).
Dr Mattson now talks about exercise...it is absolutely OK to exercise on fast days. It makes no sense that our distant ancestors would have survived if they hadn't been able to chase down an antelope when they hadn't eaten! He also mentions that IF and exercise seem to cause similar changes to the body. Dr Mosley recommends exercise for maximum health benefits. Going out for a stroll or a run etc suppresses appetite.
Fourth caller...what about starvation mode? Dr Mosley says this is one of the great myths of diet based on research done on people whose body fat dropped to 8%. In fact, cutting calories for one day increases metabolic rate which would be an evolutionary advantage...more able to get up and find food. Dr Mattson concurs that fasting improves brain function but doesn't know yet...research in progress.
Missed a caller there cos of a phone call..sorry!
Next caller asks about the Fast-5 diet (or 19:5 as we might term it). Dr Mattson says the shift to fat burning occurs at around 12 to 18 hours of fasting so yes, it should work. Dr Mosley says he tried 19:5 and he didn't like it because he loves breakfast!
Next caller asks about using longer fasting in a clinic to counteract cancer. Dr Longo says there are clinics that do long fasts as a treatment for certain diseases. He says it must be done in a clinic though and it may become more widely used in future.
Next caller asks about the carbohydrate content of food especially sugars and its effect on dementia. Dr Mosley promotes the mediterranean diet (which he describes as lots of veggies, not too much meat, a bit of wine, not so much white pasta, rice, bread, sugar etc). He thinks very low carb diet is a bad idea (due to the nutritional content of complex carbs).
Next caller is a competitive athlete...how can he incorporate fasting into his lifestyle? Dr Mosley says exercise in the fasting state results in more fat burning. Dr Mattson agrees that exercise while fasting is good. The main thing is to work out an optimal weight for your sport and adjust fasting to keep at that weight.
Diane asks each expert where fasting research is going.
Dr Longo says the role of fasting on body repair
Dr Mosley says the role of 5:2 on diabetes and reversing diabetes (studies in Norway ongoing)
Dr Mattson says they're trying to extend animal studies to humans.
The End.
Thank you SO much for making all the notes Caroline it was very interesting. It's very kind of you.
Tanks very much for the summary Caroline. Interesting stuff.
Brilliant Caroline! thank you so much for all your hard work!
Thank you Caroline. Nice to know that research is ongoing and that we might be helping in our own way!
Thank you, Caroline, that's a huge amount of work you've just done for us!!
Hope you get a bunch of flowers at least from MM for all the logging & analysis of our results, and for using them unreferenced!
Hmmm, yes I've been feeling that, for myself personally, going super-low-carb, I'd be missing out on a lot of micronutrients, including fibre & resistant starch etc
Hugely interesting read!
Hope you get a bunch of flowers at least from MM for all the logging & analysis of our results, and for using them unreferenced!
Hmmm, yes I've been feeling that, for myself personally, going super-low-carb, I'd be missing out on a lot of micronutrients, including fibre & resistant starch etc
Hugely interesting read!
Wow thanks for that Caroline. And what a great summary.
Caroline
xXx
I'm the other half of "Bean and Oates" always will be.
xXx
I'm the other half of "Bean and Oates" always will be.
Thank you very much Caroline for taking the trouble to write this down for us. Very interesting & hopeful that the health benefits are being supported by more ongoing research. It looks like we all chose wisely embarking on 5:2 for weight loss as well as our future better health 
Thanks Caroline, that made interesting reading.
This is the year that I shrink out of my clothes! 
Please sponsor me here and help me raise funds in memory of a beautiful young woman.
Please sponsor me here and help me raise funds in memory of a beautiful young woman.
Thank you for the great summary!!
Hi - just listened to this on this link: http://thedianerehmshow.org/audio-player?nid=18776. I've been doing the 5:2 since last March but fell off the bandwagon in December. Am back now, though!!
carorees wrote: I made some notes...
...
Dr Michael Mosley reports on OUR results (at least I think it's us...we are described as 'my colleagues' who are running a website tracking weightloss of over 5000 people doing 5:2)!
...
Thank you for a thorough summary.
On a related note, did the report from this thread:
post126684.html?hilit=analysis#p126684
get sent to Dr Mosley? (I couldn't find any mention of it in that thread.)
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